ABSTRACT Conventional Inverters have the drawbacks of producing high voltage stress, low-efficiency, and high temperature and are limited to small scale industrial applications. Hence for large scale industries, high-power applications and grid-connected renewable energy systems, the concept of Multi-level Inverters is the best choice. Multi-level Inverter promises a lot of advantages such as improved sinusoidal output voltage waveforms with reduced Total Harmonic Distortion [THD] over a conventional Inverter. This paper presents the design of different levels of Cascaded H-Bridge Multi-level Inverter for grid connected Photovoltaic system with reduced Total Harmonic Distortion [THD] using MATLAB/Simulink. A real time 66/11kV Santhe bachalli Sub- Station of KPTCL, Mysuru which is having 2 MW Solar Power Generation integrated to the Sub-Station at 11kV reference is considered for performance evaluation of proposed Multi-level Inverter. Keywords: Total Harmonic Distortion, Cascaded H-Bridge Multi-level Inverter, Photovoltaic System, Grid Connected